University of Calgary researcher Dr. Jeff Dunn is interviewed about new technology developed by the university to detect and monitor concussions. (Jeff McIntosh/The Canadian Press)

Scientists use MRIs to curb use of rats, mice in medical research

Researchers use a small MRI to test possible treatments for cancer, strokes and multiple sclerosis

Medical scientists at the University of Calgary have taken steps to minimize the impact on mice and rats used in their experiments.

The university’s Cumming School of Medicine is outfitted with a small MRI that researchers use as they test possible treatments for cancer, strokes and multiple sclerosis.

“It’s one of the premier ones in Canada,” said Jeff Dunn, director of the school’s Experimental Imaging Centre.

“Anything under 500 grams fits in there, so mostly rats and mice. We use those in medical research obviously for preclinical assessment, how the disease progresses and possibly even more importantly if the treatment is functional.”

The MRI has been in use since 2004. The lab is also equipped with a blood gas analyzer, so tests can be done using blood samples taken from the animals in much the same way they are collected from human patients.

It’s a far cry from when scientists would use rats and mice and have to dissect them at every test stage.

“It really reduces the use of animals in research because, for a time-course study of treatment, we don’t have to do a whole bunch of animals,” Dunn said.

“You can take a small number and follow them over months to see how the treatment is working.”

READ MORE: Animal rights group appeals B.C. court decision over euthanized bear cub

Any research facility receiving government funding is subject to rules set out by the Canadian Council on Animal Care.

Spokeswoman Sandra MacInnis says the organization wants to ensure animal-based science in Canada takes place only when necessary and that the animals receive optimal care.

“For example, when selecting a research model, they must first consider all possible alternatives to animal models, such as computer or cell-culture models,” she wrote in an email.

The executive director of the Vancouver-based Animals in Science Policy Institute says efforts by the University of Calgary and others to use the equipment are a matter of debate.

Elisabeth Ormandy, a former researcher, said putting a mouse under an MRI scanner requires sedation or anesthesia and could be considered a source of distress for an animal since it could happen several times.

“It depends on our own personal ethics,” Ormandy said. “For people who care about that one individual mouse, that (MRI) might still not be OK.”

But she said some people might argue “it’s better to cause a little bit more suffering to one mouse instead of moderate suffering to 10 mice.”

An animal rights organization said there’s no need to use animals in tests at all when computer modelling can be just as useful.

“All things else being equal, certainly hurting and killing fewer animals is better than hurting and killing more animals,” said Jeremy Beckham, research associate with People for the Ethical Treatment of Animals.

But he said that loses the bigger question a little bit.

“There’s not any real basis to think they feel pain any less than, say, a dog or a cat,” Beckham said.

“We’ve bred dogs and cats to be our companions, so we’ve got a little bit more of an emotional attachment to them. But the ethical issues of using rats and mice are staring us in the face just as strongly.”

Bill Graveland, The Canadian Press

Like us on Facebook and follow us on Twitter.

Just Posted

Hwy 24 closed west of Bridge lake due to motor vehicle incident

No further information is available at this time.

F350 stolen and smashed into 108 Mile Esso

The weekly police report for the South Cariboo area

What are you hoping for in the upcoming municipal election?

The weekly web poll for the 100 Mile Free Press

Paranormal conference coming to 100 Mile House

Paracon will be a celebration of everything weird and strange

100 Mile House preparing for another Orange Shirt Day

People of non-First Nations ancestry should listen to the stories of First Nations people for reconciliation

VIDEO: Rare close encounter with whale pod spotted off B.C. waters

Pod of southern resident orca whales breach within arms length of whale watchers

Veterans Affairs ordered to take second look before supporting vets’ relatives

Liberal government ordered officials to adopt a more critical eye

Dead B.C. motorcyclist was member of group that raced down mountain road

Some group members record their rides on Strathcona Parkway and post times to page

Indigenous athletes in spotlight at BC Sports Hall of Fame

New gallery to feature Carey Price, Kaila Mussel and Richard Peter

B.C. couple who went missing on flight from Edmonton named by family

Family released a statement Wednesday saying they’re still intent on finding the two-seater plane

VIDEO: A close look at what you were breathing during the B.C. wildfire season

Electron microscope images show soot and tar particles generated by worst B.C. fire season

B.C. woman donates $250,000 to ovarian cancer research for friends

Two of Patty Pitts’s friends passed away from the disease within a year

B.C. could provide clues as to how New Brunswick electoral results shake out

Premier Christy Clark faced a strikingly similar scenario following the province’s 2017 election

Ottawa working to iron out kinks in public alert system

The alerts are being credit with saving lives during last week’s tornadoes

Most Read